Malignant Hyperthermia (MH)

Malignant Hyperthermia (MH) is an inherited disorder of skeletal muscle characterised by hypercarbia, rhabdomyolysis, generalised skeletal muscle contracture, cardiac dysrhythmia, and renal failure, that develops on exposure to succinylcholine or volatile anaesthetic agents.

 

Specific interventions, including use of the calcium release channel antagonist dantrolene, are efficacious in reversing signs of the canine syndrome.